Osiris: New Dawn is set in the year 2046, in which humans are starting to venture into interplanetary travel. The player is sent to the Gliese 581 system by the United Nations of Earth (U.N.E.) as a member of the second colonization team. The team is sent out to study the planets to see if they are habitable. The spacecraft malfunctions due to the light speed travel and crashes onto a deserted planet, which will become the player's starting planet. In order to survive, the player must build a base while trying to prevail over the "unpredictable weather conditions".